Stan van de Graaf is Professor in Experimental Hepatology and Metabolism of the Amsterdam University Medical Center and head of the Tytgat Institute for Liver and Intestinal Research housing ~70 investigators. From 2017-2024 he was director of the research institute Amsterdam Gastroenterology, Endocrinology and Metabolism with ~95 Principal Investigators. He is recipient of an European Research Council Starting grant, the UEG Rising Star Award in 2018, the NASL Distinguished Hepatologist Award in 2025 and Dutch VENI, VIDI, and VICI grant laureate. His main research interests are bile flow, regenerative and metabolic processes in liver, with a focus on transport and signalling processes. Furthermore, he is coordinator of the Dutch ‘ARREST’ consortium financed by the NWA-ORC program of NWO. The ARREST consortium combines pioneering experts in liver perfusion and organoid biology and includes Dutch liver transplant centers (Erasmus MC, UMCG, LUMC), liver researchers from Amsterdam, Utrecht, Rotterdam, and TNO. Companies and societal partners are part to ensure the results will reach implementation in liver research in general and liver transplantation and regeneration in specific. ARREST will provide groundbreaking liver models using normothermic machine perfusion, a technique used to keep livers functioning outside the body. We will demonstrate the applicability of these models to test novel therapies to improve liver function in patients and to develop regenerative medicine approaches to increase livers available for transplantation.