Dr. Nils Haep is a clinician scientist and a surgeon at the departement of surgery at Charité in Berlin. His clinical expertise includes hepatopancreatobiliary surgery, minimally invasive surgery, and abdominal organ transplantation.
His research focuses on translational hepatology and regenerative medicine, with particular emphasis on developing innovative therapeutic strategies for end-stage liver disease. A central component of his work is a nationally funded project, which aims to restore marginal donor livers using hepatocyte cell therapy during ex vivo machine perfusion. This approach combines cutting-edge perfusion technology with stem cell-derived hepatocytes to improve organ function and expand the donor pool for liver transplantation .
In this context, Dr. Haep works at the interface of surgery, stem cell biology, and gene and cell therapy, contributing to the development of scalable hepatocyte production from induced pluripotent stem cells and their application in organ reconditioning. His broader research interests include genetic determinants of liver disease, such as genetic influences in steatotic liver disease, and mRNA-based therapeutic approaches using lipid nanoparticles.
Dr. Haep previously conducted postdoctoral research at the University of Pittsburgh, where he contributed to advances in bioengineered liver tissue and hepatocyte biology. He is currently a fellow of the Berlin Institute of Health (BIH) Clinician Scientist Program and is dedicated to translating regenerative therapies into clinical applications for patients with liver failure.